Frequently asked questions

A lab-engineered collagen protein designed to closely resemble human collagen, produced without animal-derived ingredients using recombinant DNA technology.

Yes, Colsigen’s humanized Type III collagen has the exact same amino acid sequence (100% homology) as the Type III collagen naturally found in the human body—produced recombinantly via controlled fermentation for purity and safety.

Not at all. Colsigen® is based on recombinant humanized type III collagen, bio-identical to what’s naturally found in youthful human skin. Unlike collagen from animals, it offers precise compatibility, better bioavailability, and targeted skin regeneration.

Our formulations are based on biotechnology-derived, non-animal proteins to ensure consistency, safety, and ethical sourcing. This approach also minimizes the risk of immune reactions.

Yes. Colsigen® contains no animal-derived ingredients. The collagen is produced through recombinant biotechnology using a non-animal fermentation process.

Colsigen® is registered FDA Class I Medical Device.

Absolutely. It is produced through animal-free recombinant biotechnology in controlled bioreactors, it avoids animal-borne contaminants and ensures a high level of purity and consistency.

No. Colsigen® products are fragrance-free and dye-free to reduce the risk of irritation and support use on sensitive or post-procedure skin.

Recombinant humanized collagen is gentle:
– Free from animal-source collagen proteins: Because it is not derived from bovine or porcine sources, it avoids species-related immune reactions sometimes associated with animal collagen.
– Tested for safety: It has undergone rigorous in vitro and in vivo safety evaluations, including skin irritation and sensitization testing.

ColsigenMist™ is formulated without added fragrance. The perceived odor primarily originates from the natural scent of the mixed raw materials, and no masking fragrance is added. In spray form, the odor may be temporarily amplified, which is a normal phenomenon.

Colsigen® is well-tolerated. There have been no side effects observed with the proper use of Colsigen® products. In rare cases, minor irritation may occur due to individual sensitivities. Discontinue use if irritation persists.

No. The formula contains no fragrance, alcohol, or harsh ingredients and is designed to be gentle. During development, the product was also tested for irritation potential and other biocompatibility parameters, confirming it is safe and well tolerated. Temporary stinging on very sensitive or recently treated skin is a normal response.

Yes. Colsigen® does not contain gluten or gluten-derived ingredients.

Yes. Colsigen® is formulated for sensitive skin and has been tested for irritation potential and biocompatibility during development, confirming it is safe and well-tolerated.

No, Colsigen® does not replace Stratacel®. Colsigen® may be used in combination with Stratacel®: first apply Colsigen® and let it dry, then apply Stratacel® on top to create a semi‑permeable protective barrier which may help maintain the benefits of the Colsigen® mask ingredients.

Find more information about Stratacel here: www.stratacel.com

Colsigen® brings recombinant humanized type III collagen, a bioengineered, non-animal collagen formulated to soothe, hydrate, and rejuvenate sensitive or compromised skin, repairing the damage from cosmetic procedures and daily environmental stresses. Together with Stratpharma’s current offerings, Colsigen® provides a complementary approach to support hydration and skin comfort.

Colsigen® is specifically designed to be clinic and retail ready. It is available in Box of 5 single-use masks and Box of 25 single-use masks, and can be sold either as a complete unit or as individual sachets, which are individually barcoded and UDI-labeled. This flexible format makes Colsigen® ideal for post-procedure aftercare programs, in-clinic resale, bundled treatment packages, and professional aesthetic retail environments.

Colsigen® is indicated for superficial wounds, not open wounds where the epidermis has been completely removed.

Yes. After procedures like laser treatments, the skin barrier is temporarily weakened. This allows products to penetrate more deeply and can briefly stimulate nerve endings, causing short-lived stinging.

It usually fades within a few minutes. If you get strong pain, persistent redness, swelling, itching, or a rash, stop using it and contact your physician.

Cleanse your face thoroughly with lukewarm water. Apply the mask gently to your clean, dry skin. Relax for 20 minutes while the mask works. Allow to absorb naturally or pat in gently for extra hydration and glow.

Cleanse your face thoroughly with lukewarm water. Hold the bottle 15–20 cm away from your face. Spray evenly across the skin, keeping eyes closed. Allow to absorb naturally or pat in gently for extra hydration and glow.

Yes. They are commonly used post-treatment for hydration and comfort, but they are not intended for open wounds. Always consult with your healthcare professional.

Colsigen® can be used following both ablative and fractional laser resurfacing procedures. It is suitable for compromised skin after aesthetic treatments and integrates easily into post-procedure protocols. Colsigen® is a class I medical device made from non-animal derived materials, fragrance and alcohol-free and is formulated with injectable grade materials reducing the risk of reaction.

Both can be used daily or as needed, even multiple times per day in the case of ColsigenMist™. They are safe for regular use on all skin types.

Yes, it can be used under or over makeup as a hydration boost.

- Patients’ post-cosmetic procedures (laser resurfacing, microdermabrasion, microneedling, superficial peels…)
- Individuals with sensitive, dry, or stressed skin
- Everyday use, for all skin types

Colsigen® does not require any special storage conditions under normal use.

Colsigen® has a 36‑month shelf life from the manufacturing date when stored properly. Please refer to the expiry date printed on each package to ensure it is still within this period.

Note for Colsigen Refresh™: Once the sachet is opened, it will dry out quickly—use immediately for best results.

No, temperature does not significantly affect recombinant collagen stability in Colsigen® under normal storage and use conditions.

You can check our webshop and select your country to see whether Colsigen® is currently available in your region.

Yes. Colsigen® is available through aesthetic and dermatology clinics, where it can be incorporated into professional treatment protocols and post-procedure care. Please ask your clinic if Colsigen® is available in your area. Alternatively, you can also easily order Colsigen® from our online store.